From Protein Structure to Function with Bioinformatics by Daniel J. Rigden PDF

By Daniel J. Rigden

ISBN-10: 9402410678

ISBN-13: 9789402410679

This publication is set protein structural bioinformatics and the way it will probably aid comprehend and are expecting protein functionality. It covers structure-based equipment which could assign and clarify protein functionality according to total folds, features of protein surfaces, prevalence of small 3D motifs, protein-protein interactions and on dynamic houses. Such tools aid extract greatest worth from new experimental buildings, yet can frequently be utilized to protein versions. The ebook additionally, consequently, offers accomplished insurance of tools for predicting or inferring protein constitution, overlaying all structural periods from globular proteins and their membrane-resident opposite numbers to amyloid buildings and intrinsically disordered proteins.

The ebook is divided into large sections, the 1st overlaying easy methods to generate or infer protein constitution, the second one facing structure-based functionality annotation. each one bankruptcy is written through international specialists within the box. the 1st part covers tools starting from conventional homology modelling and fold reputation to fragment-based ab initio tools, and encompasses a bankruptcy, new for the second one version, on constitution prediction utilizing evolutionary covariance. Membrane proteins and intrinsically disordered proteins are each one assigned chapters, whereas new chapters care for amyloid buildings and skill to foretell modes of protein-protein interplay. the second one part comprises chapters protecting useful range inside of protein folds and capability to assign functionality according to floor houses and habitual motifs. additional chapters hide the major roles of protein dynamics in protein functionality and use of automatic servers for functionality inference. The e-book concludes with chapters masking case reviews of constitution prediction, dependent respectively on crystal buildings and protein versions, supplying a number of examples of real-world utilization of the tools pointed out previously.

This publication is concentrated at postgraduate scholars and educational researchers. it truly is most glaringly of curiosity to protein bioinformaticians and structural biologists, yet must also function a advisor to biologists extra generally through highlighting the insights that structural bioinformatics provides into proteins in their interest.

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Read e-book online Designing User Studies in Informatics (Health Informatics) PDF

By Gondy Leroy

ISBN-10: 0857296213

ISBN-13: 9780857296214

ISBN-10: 1447126963

ISBN-13: 9781447126966

This publication offers a pragmatic, hands-on consultant to accomplishing person reports in informatics. Its objective is to give an explanation for the principles of alternative experimental designs including the ideal statistical analyses for experiences in general carried out in computing. universal blunders are highlighted including guidance on how they need to be shunned. The e-book is meant for complex undergraduate scholars, starting graduate scholars and as a refresher for any researcher comparing the usefulness of informatics for individuals by way of doing consumer stories. With transparent, non-technical language, primary strategies are defined and illustrated utilizing different examples. as well as the principles, functional easy methods to beginning, buying permission, recruiting contributors, carrying out and publishing stories are incorporated. A how-to consultant, within the type of a cookbook, can also be incorporated. The cookbook recipes could be step by step or adjusted as worthwhile for various reports. every one recipe comprises step by step directions and urban advice.

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Download PDF by Wei Wu,Hani Choudhry: Next Generation Sequencing in Cancer Research: Volume 1:

By Wei Wu,Hani Choudhry

ISBN-10: 1461476445

ISBN-13: 9781461476443

ISBN-10: 1489988084

ISBN-13: 9781489988089

​​​​This quantity provides an interdisciplinary point of view of applying subsequent new release Sequencing (NGS) know-how to melanoma learn. It aims to systematically introduce the idea that of NGS, quite a few NGS systems and their useful implications in melanoma biology.This special and complete text will combine the extraordinary NGS know-how into quite a few cancer research projects as against such a lot books which offer a detailed description of the expertise. This quantity will present real experimental effects with concrete facts processing pipelines, talk about the bottleneck of every platform for genuine venture in melanoma research. In extra, unmarried melanoma telephone sequencing because the evidence of proposal could be brought during this e-book, besides state of the art details provided will aid the meant viewers to advance a entire knowing of the NGS know-how and functional entire genome sequencing info research and speedily translate into their very own study, particularly within the box of melanoma biology. 

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Download e-book for iPad: Humanbiologie für Lehramtsstudierende: Ein Arbeits- und by Armin Baur

By Armin Baur

ISBN-10: 3662453673

ISBN-13: 9783662453674

Dieses Buch bietet dem Leser die Möglichkeit, sich nach eigenem Interesse und nach Studienrichtung (Lehramt für Primarstufe, Sekundarstufe I, Sekundarstufe II) mit differenzierten Inhalten, Anregungen und Hilfestellungen, die individuelles Lernen ermöglichen, in die Humanbiologie einzuarbeiten. Hierzu sind die Themen der Humanbiologie, welche später für die Schule correct sind, kurz und knapp dargestellt. Das Buch enthält Aufgaben und Abbildungen zum Beschriften (jeweils mit Lösungen). Über die Verlagsinternetseite werden Zusatzübungen, Filme und Anleitungen zum Bau von Modellen zur Verdeutlichung von Inhalten bereitgestellt.

Aus dem Inhalt:
- Zelle und Gewebe
- Atmung
- Herz, Kreislauf, Blut und Lymphe
- Bewegung
- Sinnesorgane (Auge, Ohr, Haut)
- Nervensystem
- Hormonsystem
- Ernährung und Verdauung
- Wasser-Elektrolyt-Haushalt
- Fortpflanzung und Entwicklung

Das Buch wurde für Lehramtsstudierende Biologie geschrieben, eignet sich aber auch für andere Biologiestudierende und Leser, die einen Einblick in das Thema bekommen möchten.

Über den Autor
Dr. Armin Baur lehrt momentan Humanbiologie an der PH Schwäbisch Gmünd. Bei der Erstellung des Buches hat er seine früheren Erfahrungen aus dem Studium, aus seiner Tätigkeit als Lehrer und Ausbildungslehrer und aus seiner derzeitigen Lehrtätigkeit an der Hochschule einfließen lassen.

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Download e-book for iPad: The Anatomy and Physiology Learning System - E-Book by Edith Applegate

By Edith Applegate

ISBN-10: 0721659039

ISBN-13: 9780721659039

ISBN-10: 0721680208

ISBN-13: 9780721680200

Who stated studying A&P cannot be enjoyable? The Anatomy and body structure studying procedure, 4th Edition makes it effortless to profit general constitution and serve as of the physique, and summarizes the typical issues present in each one physique process. Written through famous educator Edith Applegate, this publication combines transparent, crisp writing with hundreds and hundreds of bright illustrations. This variation incorporates a superior emphasis on clinical vocabulary, so that you comprehend key phrases prior to you study anatomy. a wide range of attractive positive aspects simplifies body structure thoughts, and an Evolve web site helps the e-book with a wealth of latest studying possibilities. whether you've gotten very little heritage in technology, you'll examine the A&P you want to input your career!

  • A transparent and concise writing style makes the publication effortless to learn and comprehend, no matter if you've gotten a restricted heritage in science.
  • Quick Check questions allow you to fee your comprehension at a variety of issues inside of a chapter.
  • Chapter quizzes provide keep in mind, idea, and alertness inquiries to money your realizing of A&P concepts.
  • An Evolve website contains on-line tutoring, a Body Spectrum coloring ebook, Anatomy & body structure Pioneers bins with short biographies of trailblazers in technological know-how and medication, 3-D animations, an audio word list, Spanish pronunciations of key phrases, and regularly requested questions.
  • Outlines and objectives at first of every bankruptcy assist you prioritize your study.
  • Key terms are highlighted that can assist you learn, pronounce, and spell vital scientific words.
  • A glossary presents definitions and a pronunciation consultant for key terms.
  • Functional Relationships pages illustrate the relationship among each one person procedure and the opposite physique platforms, exhibiting how all platforms paintings together.
  • Representative Disorders describe the typical overall healthiness concerns linked to each one physique system.
  • Focus on Aging boxes describe the results of getting older on physique systems.
  • Quick Applications boxes attach the cloth to real-world scenarios.
  • From the Pharmacy boxes describe universal medicines for every physique approach and comprise a quick description of the drug and its motion, universal makes use of, and abbreviations.
  • 100 new top quality illustrations assist you visualize anatomical positive factors and physiological processes.
  • Chapter summaries and vocabulary quizzes were extra to the tip of every chapter.
  • New Building Your scientific Vocabulary section covers the heritage of clinical phrases, providing you with the construction blocks to take advantage of and realize new terms.

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Read e-book online Human Hand Function PDF

By Lynette A. Jones,Susan J. Lederman

ISBN-10: 0195173155

ISBN-13: 9780195173154

Human Hand Function is a multidisciplinary publication that reports the sensory and motor elements of ordinary hand functionality from either neurophysiological and behavioral views. Lynette Jones and Susan Lederman current hand functionality as a continuum starting from actions which are primarily sensory in nature to people who have a robust motor part. They delineate 4 different types of functionality alongside this sensorimotor continuum--tactile sensing, energetic haptic sensing, prehension, and non-prehensile expert movements--that they use as a framework for reading and synthesizing the implications from a extensive diversity of experiences that experience contributed to our figuring out of the way the traditional human hand functions.

The booklet starts with a ancient review of analysis at the hand and a dialogue of the hand's evolutionary improvement when it comes to anatomical constitution. the next chapters evaluate the examine in all the 4 different types alongside the continuum, overlaying themes equivalent to the in depth spatial, temporal, and thermal sensitivity of the hand, the position of hand hobbies in spotting universal gadgets, the keep an eye on of attaining and greedy pursuits, and the association of keyboard talents. Jones and Lederman additionally research how sensory and motor functionality develops within the hand from beginning to previous age, and the way the character of the tip effector (e.g., a unmarried finger or the total hand) that's used to have interaction with the surroundings impacts the categories of data received and the initiatives played. The publication closes with an evaluate of ways easy examine at the hand has contributed to an array of extra utilized domain names, together with conversation platforms for the blind, haptic interfaces utilized in teleoperation and virtual-environment functions, exams used to evaluate hand impairments, and haptic exploration in paintings. Human Hand Function should be a necessary source for pupil researchers in neuroscience, cognitive psychology, engineering, human-technology interplay, and physiology.

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New PDF release: Melanins and Melanogenesis

By Giuseppe Prota

ISBN-10: 0123960851

ISBN-13: 9780123960856

ISBN-10: 0125659709

ISBN-13: 9780125659703

This quantity covers all points of melanin pigmentation, supplying a concise, entire photograph of recent wisdom received on the frontiers of analysis. It attracts seriously at the author's 30-year task within the box and his carrying on with paintings with experts of largely varied disciplines. The middle of the amount bargains with the constitution, physicochemical houses, and biosynthesis of the foremost periods of melanin pigments, together with neuromelanins. extra discussions contain the biology of a few of the sorts of pigment-producing cells, the constitution and mode of motion of tyrosinase, and the chemistry of urinary melanogens and their biomedical purposes as metabolic markers of melanocyte task, specially for the follow-up of malignant cancer. eventually, the quantity considers growth within the photobiology and photochemistry of melanins, with designated emphasis at the debatable position of those pigments in pores and skin photoprotection. Melanins and Melanogenesis is supreme as a simple advisor for beginners, and a convenient resource of particular info for practitioners in educational, scientific, and commercial settings.

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Download PDF by Josef Tomasits,Paul Haber: Leistungsphysiologie: Grundlagen für Trainer,

By Josef Tomasits,Paul Haber

ISBN-10: 3211252215

ISBN-13: 9783211252215

Allgemein geltende Grundlagen der Leistungsphysiologie, wie z.B. Leistungsfähigkeit, bilden den Schwerpunkt des Buches. Es werden Themen wie Energiestoffwechsel, Kreislauf und Atmung während einer Belastung und unter Berücksichtigung der Prinzipien der medizinischen Trainingslehre behandelt. Ergänzt wurde die 2. Auflage mit den neuesten Ergebnissen aus der sportmedizinischen Forschung. Die Grundregeln der Planung und Gestaltung systematischen Trainings von Ausdauer und Kraft, sowie die dazugehörige Ernährungsphysiologie werden leicht verständlich dargestellt. Neu ist auch das format mit zahlreichen anschaulichen Grafiken. Hauptzielgruppe sind coach, Physiotherapeuten und Masseure, aber auch interessierte Laien. Den Physiotherapeuten kommt eine immer größere Bedeutung als Übungsleiter für therapeutisches education im Bereich der Rehabilitation zu. Dieses Buch bietet eine solide foundation für qualifiziertes Vorgehen bei der Anleitung zu rehabilitativem education und zur Beratung.

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David S. Smith,Michael Locke's Muscle (Ultrastructure of cells and organisms) PDF

By David S. Smith,Michael Locke

ISBN-10: 0124541453

ISBN-13: 9780124541450

Muscle goals to contemplate points of the constitution and serve as of chosen muscle cells, essentially from vertebrates and arthropods, with using diagrams, gentle micrographs, and electron micrographs.
The publication starts off by way of in short tracing the ancient improvement of stories on muscle tissue. Pioneering stories confirmed that whereas many cells express the valuables of contractility to a constrained measure, muscle cells, no matter if striated or unstriated, are most glaringly tailored to their functionality by way of hypertrophy of the fibrillar fabric instead of through acquisition of a different set of cytoplasmic elements.
Separate chapters conceal issues akin to the striated muscle; the association of myofibrils in striated muscle; the sarcomere and the molecular occasions of contraction; cytochemical demonstration of myofibrillar ATPase; and edition within the actin. next chapters take care of the capabilities of the mitochondria, nucleus, neuromuscular junction, plasma membrane, transverse tubular process, and sarcoplasmic reticulum. additionally mentioned are the cardiac muscle, tender muscle, and muscle insertions.

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Download PDF by Michel Gautherie: Whole Body Hyperthermia: Biological and Clinical Aspects

By Michel Gautherie

ISBN-10: 0387545603

ISBN-13: 9780387545608

ISBN-10: 3642845983

ISBN-13: 9783642845987

1. 1 historical past neoplastic illnesses that are at present refractory to traditional remedy. All features of either preclinical Anticancer results of increased (noncauterizing) tem­ and medical WBH, starting from molecular biology perature have been first saw in historical Egyptian instances and body structure to WBH methodologies and medical (Oleson and Dewhirst 1983). Hippocrates trials, should be comprehensively reviewed. it's our in­ (460-377 B. C. ) later included fever remedy right into a tention to supply the reader with a definitive source homeopathic method of ailment (Le. , treating a dis­ of to guage the present prestige and destiny capability ease with a symptom of that disease). within the fourth WBH. In so doing, we'll try and current the vari­ century, Refus of Ephesus encouraged using fever ous views and insights derived from the efforts induction to regard malignant ailments (Kluger 1980). of investigators during the global. we are hoping this within the 19th century tumor regressions accompa­ will motivate an improved investigative dedication nying excessive fevers have been mentioned either by way of Busch and to this fascinating and cutting edge method of melanoma Bruns (Busch 1866; Bruns 1888). on the finish of the therapy.

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